Vinorelbine Injection

Vinorelbine Injection

Vinorelbine belongs to the class of medications called as antineoplastics. It prevents proliferation and maturation of cancer cells which eventually get destroyed. This injection is used to treat non-small cell lung cancer.

It is also indicated in metastatic breast cancer patients, previously treated with anthracyline andor taxane therapy.

Precautions

Administration of Vinorelbine Injection should be done only by physicians experienced with cancer chemotherapeutic agents.

Blood counts are required to be taken before each dose. The dosage should be reduced or discontinued upon evidence of abnormal depression of the bone marrow.

Contraindications

Vinorelbine Injection is contraindicated in patients with known hypersensitivity to this drug.

In addition, this injection is contraindicated in patients who have drug-induced severe granulocytopenia or severe thrombocytopenia.

Side effects

Seek immediate medical attention if you experience signs of an allergic reaction such as bronchospasm (wheezing, chest tightness, trouble breathing), hives, difficulty in breathing, fever, chills, flu symptoms, mouth and throat ulcers, bloody or black stools, pale skin, easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), rapid heart rate, rapid and shallow breathing, fainting, cough, severe constipation, stomach pain, numbness, burning, pain or tingly feeling, nausea, sweating, burning, redness, swelling or skin changes.




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This injection is to be administered only under the supervision of your doctor. Epirubicin should be injected slowly into a vein. Do not inject into a muscle or under the skin. If this medication by coincidence leaks into the skin/muscle around the injection site, it may cause serious damage. Tell your doctor without delay if you observe redness, pain or swelling at or near the injection site.

Contraindications for Epirubicin Injection

Use of this medicine should be avoided in those are allergic to epirubicin or to any of the ingredients of the medication, allergic to other anthracycline-type medications like doxorubicin, breast-feeding, recent heart attack, heart failure, irregular heart rhythm, severe heart disease, severe liver impairment.

Pharmacological Action of

Epirubicin forms a complex with DNA by intercalation of its planar rings between nucleotide base pairs, with consequent inhibition of nucleic acid (DNA and RNA) and protein synthesis.Such intercalation triggers DNA cleavage by topoisomerase II, resulting in cytocidal activity. Epirubicin also inhibits DNA helicase activity, preventing the enzymatic separation of double-stranded DNA and interfering with replication and transcription

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Side effects of Irinotecan Injection

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Leuprolide Anti cancerous Injectables

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With an objective to serve clients in best possible manner, we have been betrothed in providing high quality Leuprolide Injection. This injection is ideal for the treatment of anemia. The offered injection is available in medical stores, hospitals and other similar places. The offered injection is formulated at modern processing unit by our adept professionals using high grade chemicals. In addition to this, the provided Leuprolide Injection can be bought from us in moisture proof packaging at cost effective rates.

Key Points:

Longer shelf life Safe and reliable Quick acting Accurate composition

 


 

Category: Anti-neoplastic
Composition- : Each 0.5ml Contains : Leuprolide Acetate  1mg
Leuprolide acts as an agonist at pituitary GnRH receptors. By interrupting the normal pulsatile stimulation and the desensitization of the GnRH receptors; it indirectly down regulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol .

Specification- pH range – : 5.5 to 6.5
Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone. It is a sterile, aqueous solution intended for subcutaneous injection.
Indication : Advanced prostatic carcinoma when orchidectomy or oestrogen administration is not indicated.
Dosage :- SC inj., 1 mg single dose.
Contraindications:- Pregnancy, in women who may become pregnant while receiving the drug, and during lactation. Sensitivity to benzyl alcohol (found in leuprolide injection). Undiagnosed abnormal vaginal bleeding. Hypersensitivity to GnRH or GnRH agonist analogs. The 30-mg depot in women.
Precautions:- Patients with metastatic vertebral lesions and/or with urinary tract obstruction should be closely observed during the first few weeks of therapy. Patients with known allergies to benzyl alcohol, an ingredient of the drug's vehicle, may present symptoms of hypersensitivity, usually local, in the form of erythema and induration at the injection site.
Drug interaction: Administration of leuprolide acetate in therapeutic doses results in suppression of the pituitary-gonadal system. Normal function is usually restored within 4 to 12 weeks after treatment is discontinued. Administration of leuprolide acetate in therapeutic doses results in suppression of the pituitary-gonadal system. Normal function is usually restored within 4 to 12 weeks after treatment is discontinued.
Adverse Effect-: High blood pressure, ischemia, insomnia, constipation, urinating more often than usual, bone pain, loss of movement in any part of your body; swelling, rapid weight gain.
Storage: : Store unopened bottles in the refrigerator. Vials can be kept at room temperature (less than 86 degrees F or 30 degrees C). Do not freeze. Protect from light.
Purity:- 99.5%
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