Leuprolide Anti cancerous Injectables

Leuprolide Anti cancerous Injectables

With an objective to serve clients in best possible manner, we have been betrothed in providing high quality Leuprolide Injection. This injection is ideal for the treatment of anemia. The offered injection is available in medical stores, hospitals and other similar places. The offered injection is formulated at modern processing unit by our adept professionals using high grade chemicals. In addition to this, the provided Leuprolide Injection can be bought from us in moisture proof packaging at cost effective rates.

Key Points:

Longer shelf life Safe and reliable Quick acting Accurate composition

 


 

Category: Anti-neoplastic
Composition- : Each 0.5ml Contains : Leuprolide Acetate  1mg
Leuprolide acts as an agonist at pituitary GnRH receptors. By interrupting the normal pulsatile stimulation and the desensitization of the GnRH receptors; it indirectly down regulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) leading to hypogonadism and thus a dramatic reduction in estradiol .

Specification- pH range – : 5.5 to 6.5
Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone. It is a sterile, aqueous solution intended for subcutaneous injection.
Indication : Advanced prostatic carcinoma when orchidectomy or oestrogen administration is not indicated.
Dosage :- SC inj., 1 mg single dose.
Contraindications:- Pregnancy, in women who may become pregnant while receiving the drug, and during lactation. Sensitivity to benzyl alcohol (found in leuprolide injection). Undiagnosed abnormal vaginal bleeding. Hypersensitivity to GnRH or GnRH agonist analogs. The 30-mg depot in women.
Precautions:- Patients with metastatic vertebral lesions and/or with urinary tract obstruction should be closely observed during the first few weeks of therapy. Patients with known allergies to benzyl alcohol, an ingredient of the drug's vehicle, may present symptoms of hypersensitivity, usually local, in the form of erythema and induration at the injection site.
Drug interaction: Administration of leuprolide acetate in therapeutic doses results in suppression of the pituitary-gonadal system. Normal function is usually restored within 4 to 12 weeks after treatment is discontinued. Administration of leuprolide acetate in therapeutic doses results in suppression of the pituitary-gonadal system. Normal function is usually restored within 4 to 12 weeks after treatment is discontinued.
Adverse Effect-: High blood pressure, ischemia, insomnia, constipation, urinating more often than usual, bone pain, loss of movement in any part of your body; swelling, rapid weight gain.
Storage: : Store unopened bottles in the refrigerator. Vials can be kept at room temperature (less than 86 degrees F or 30 degrees C). Do not freeze. Protect from light.
Purity:- 99.5%



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Quality Specification: Chromatographic Purity: NLT 99%

It is a antitumour antibiotic and finds a useful application in acute leukemia & in many solid tumours. Doxorubicin is capable of cusing breaks in DNA strands and have mutagenic and carcinogenic potential. Maximum action is exerted at S phase, but toxicity is usually exhibited in G2 phase.


Composition :

Each vial contains: 
Doxorubicin Hydrochloride.10mg, 50mg, 100mg 
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Indications :

Doxorubicin has been used successfully to produce regression in disseminated neoplastic conditions such as acute lymphoblastic leukemia, acute myeloblasticleukemia, Wilms' tumor, neuroblastoma, soft tissue and bone sarcomas, breast carcinoma, ovarian carcinoma, transitional cell bladder carcinoma, thyroid carcinoma, gastric carcinoma, Hodgkin's disease, malignant lymphoma and bronchogenic carcinoma in which the small cell histologic type is the most responsive compared to other cell types.

Contraindications :

In patients with history of hypersensitivity to the drug, pregnancy, location.

Pharmacological action:

: It is a antitumour antibiotic and finds a useful application in acute leukemia & in many solid tumours. Doxorubicin is capable of cusing breaks in DNA strands and have mutagenic and carcinogenic potential. Maximum action is exerted at S phase, but toxicity is usually exhibited in G2 phase

Adverse Effects :

: Cardiotoxicity, alopecia, Bone marrow depression, alopecia, cardiomyopathy, stomatitis, vomiting and local tissue damage.

Dosage :

1.2-2.4 mg/kg body wt or 60-75 mg/sq metre of body surface given as a single dose every 3 week by slow i.v. inj. Doxorubicin has been used concurrently with other approved chemotherapeutic agents. Evidence is available that in some types of neoplastic disease combination chemotherapy is superior to single agents. The benefits and risks of such therapy continue to be elucidated. When used in combination with other chemotherapy drugs, the most commonly used dosage of doxorubicin is 40 to 60 mg/m2 given as a single intravenous injection every 21 to 28 days.

Drug interaction:

Doxorubicin is extensively metabolized by the liver. Changes in hepatic function induced by concomitant therapies may affect doxorubicin metabolism, pharmacokinetics, therapeutic efficacy, and/or toxicity. Toxicities associated with doxorubicin, especially hematologic and gastrointestinal events, may be increased when doxorubicin is used in combination with other cytotoxic drugs.

Precautions:

ECG changes, arrhythmias, hypotension, or be delayed congestive heart failure.Doxorubicin may cause heart problems, including possibly fatal heart failure. Heart problems may occur durin doxorubicin therapy or months to years after receiving this medication


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Contraindications for L-Asparaginase Injection

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Side effects of L-Asparaginase Injection

Seek medical attention, if you have any signs of an allergic reactions like hives, difficulty in breathing, swelling of your face, lips, tongue, or throat, severe pain in your upper stomach radiating to back, nausea and vomiting, fast heart rate, easy bruising or bleeding, unusual weakness etc.

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Cytarabine belongs to the group of medicines called antimetabolites which acts by inhibiting DNA polymerase. Particularly, it blocks the progression of cells from the G1 phase to the S-phase.

It is indicated in patients with acute Non-Lymphoblastic Leukaemia, Acute Myeloid Leukaemia, Acute Lymphoblastic Leukaemia, Diffuse Histiocytic Lymphomas (non-Hodgkin's lymphomas of high malignancy), Acute Lymphocytic Leukaemia, Erythroleukemia, Blast Crisis of Chronic Myeloid Leukaemia, Meningeal Leukaemia and Meningeal Neoplasms.

Precautions

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Contraindications

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Side Effects

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