Epirubicin Injection

Epirubicin Injection

Epirubicin Injection

Epirubicin injection has strong anti tumor action by interfering with the synthesis and function of DNA. The given injection is used to treat cancers of breast, lungs, ovaries, lymph system and stomach. Epirubicin is an antineoplastic in the anthracycline class which prevents abnormal growth of tissues.

Precautions for Epirubicin Injection

This injection is to be administered only under the supervision of your doctor. Epirubicin should be injected slowly into a vein. Do not inject into a muscle or under the skin. If this medication by coincidence leaks into the skin/muscle around the injection site, it may cause serious damage. Tell your doctor without delay if you observe redness, pain or swelling at or near the injection site.

Contraindications for Epirubicin Injection

Use of this medicine should be avoided in those are allergic to epirubicin or to any of the ingredients of the medication, allergic to other anthracycline-type medications like doxorubicin, breast-feeding, recent heart attack, heart failure, irregular heart rhythm, severe heart disease, severe liver impairment.

Pharmacological Action of

Epirubicin forms a complex with DNA by intercalation of its planar rings between nucleotide base pairs, with consequent inhibition of nucleic acid (DNA and RNA) and protein synthesis.Such intercalation triggers DNA cleavage by topoisomerase II, resulting in cytocidal activity. Epirubicin also inhibits DNA helicase activity, preventing the enzymatic separation of double-stranded DNA and interfering with replication and transcription




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